I'm using a ZuluSCSI Pico slim on one of my SE/30s. The Zulu firmware complains about one of the images having a LIDO SCSI driver and warns of potential problems. But, regardless of how I try to come at it I'm unable to 'UPDATE' (replace the SCSI driver) on that volume. I know that one cannot generally update the boot volume, but even after booting from a different volume the UPDATE button is grayed out. I am using a patched version of Apple HD SC Setup 7.3.5 which has no problem seeing the drive.

HD SC Setup can probably only replace its own (Apple) drivers. Best try other apps, maybe Silverlining might be able to do this. Or just re-initialize it....